产品货号：
Z35092
中文名称：
MAF抗体
英文名称：
Anti-MAF Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MAF Antibody |
| 指标别名 | c MAF;cMAF;MAF;Proto oncogene c Maf;Transcription factor Maf |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | IHC |
| 基因名称 | MAF |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human c-Maf |
| 成分 | Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Acts as a transcriptional activator or repressor.Involved in embryonic lens fiber cell development.Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation.Activates the expression of IL4 in T helper 2 (Th2) cells.Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression.Together with PAX6,transactivates strongly the glucagon gene promoter through the G1 element.Activates transcription of the CD13 proximal promoter in endothelial cells.Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction.Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development.Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter.Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters.Binds element G1 on the glucagon promoter.Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity).When overexpressed,represses anti-oxidant response element (ARE)-mediated transcription.Involved either as an oncogene or as a tumor suppressor,depending on the cell context.Binds to the ARE sites of detoxifying enzyme gene promoters. |
| Uniprot ID | O75444 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Immunohistochemistry in paraffin section (IHC) 1:20～100 |
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